CHOP Fights Cancer in Immunotherapy Trial

Adoptive cell transfer offers hope when chemotherapy fails

Immunotherapy treatments harness a patient’s own immune system to fight cancer.

In a clinical trial using data stored in their Epic database, the Children’s Hospital of Philadelphia (CHOP) studied the effectiveness of adoptive cell transfer on 30 pediatric patients with advanced acute lymphoblastic leukemia. In this form of immunotherapy, researchers genetically engineer a patient’s T cells to produce special receptors that recognize tumor cell antigens. When clinicians inject these T cells back into the patient’s body, the cells multiply and attack the cancer.

For 27 of the 30 trial participants, all signs of cancer disappeared. Two years later, 70% of the 27 patients remained in remission.

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